Abstract
AbstractTo study the neuroanatomical correlate of involuntary unilateral blinking in humans, using the example of patients with focal epilepsy. Patients with drug resistant focal epilepsy undergoing presurgical evaluation with stereotactically implanted EEG-electrodes (sEEG) were recruited from the local epilepsy monitoring unit. Only patients showing ictal unilateral blinking or unilateral blinking elicited by direct electrical stimulation were included (n = 16). MRI and CT data were used for visualization of the electrode positions. In two patients, probabilistic tractography with seeding from the respective electrodes was additionally performed. Three main findings were made: (1) involuntary unilateral blinking was associated with activation of the anterior temporal region, (2) tractography showed widespread projections to the ipsilateral frontal, pericentral, occipital, limbic and cerebellar regions and (3) blinking was observed predominantly in female patients with temporal lobe epilepsies. Unilateral blinking was found to be associated with an ipsilateral activation of the anterior temporal region. We suggest that the identified network is not part of the primary blinking control but might have modulating influence on ipsilateral blinking by integrating contextual information.
Funder
Ludwig-Maximilians-Universität München
Publisher
Springer Science and Business Media LLC
Subject
Clinical Neurology,Neurology,Radiology Nuclear Medicine and imaging,Radiological and Ultrasound Technology,Anatomy
Reference54 articles.
1. Alajouanine T, Thurel R (1933) La diplégie faciale cérébrale forme corticale de la paralysie pseudo-bulbaire (contribution à l’étude de la dissociation des activités volontaire et réflexe). Rev Neurol 40:441–458
2. Aminoff EM, Schacter DL, Bar M (2008) The cortical underpinnings of context-based memory distortion. J Cogn Neurosci 20:2226–2237. https://doi.org/10.1162/jocn.2008.20156
3. Aminoff EM, Kveraga K, Bar M (2013) The role of the parahippocampal cortex in cognition. Trends Cogn Sci 17:379–390. https://doi.org/10.1016/j.tics.2013.06.009
4. Bakar M, Kirshner HS, Niaz F (1998) The opercular-subopercular syndrome: four cases with review of the literature. Behav Neurol 11:97–103
5. Bar M, Aminoff E, Schacter DL (2008) Scenes unseen: the parahippocampal cortex intrinsically subserves contextual associations, not scenes or places per Se. J Neurosci 28(34):8539–8539
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