Author:
Ricci Lorenzo,Croce Pierpaolo,Pulitano Patrizia,Boscarino Marilisa,Zappasodi Filippo,Narducci Flavia,Lanzone Jacopo,Sancetta Biagio,Mecarelli Oriano,Di Lazzaro Vincenzo,Tombini Mario,Assenza Giovanni
Abstract
AbstractTo determine the effects of Levetiracetam (LEV) therapy using EEG microstates analysis in a population of newly diagnosed Temporal Lobe Epilepsy (TLE) patients. We hypothesized that the impact of LEV therapy on the electrical activity of the brain can be globally explored using EEG microstates. Twenty-seven patients with TLE were examined. We performed resting-state microstate EEG analysis and compared microstate metrics between the EEG performed at baseline (EEGpre) and after 3 months of LEV therapy (EEGpost). The microstates A, B, C and D emerged as the most stable. LEV induced a reduction of microstate B and D mean duration and occurrence per second (p < 0.01). Additionally, LEV treatment increased the directional predominance of microstate A to C and microstate B to D (p = 0.01). LEV treatment induces a modulation of resting-state EEG microstates in newly diagnosed TLE patients. Microstates analysis has the potential to identify a neurophysiological indicator of LEV therapeutic activity. This study of EEG microstates in people with epilepsy opens an interesting path to identify potential LEV activity biomarkers that may involve increased neuronal inhibition of the epileptic network.
Funder
‘Search of Excellence’, initiative of the Department of Neuroscience, Imaging and Clinical Sciences (DNISC) of the University of Chieti-Pescara
Università degli Studi G. D'Annunzio Chieti Pescara
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),Neurology,Radiology, Nuclear Medicine and imaging,Radiological and Ultrasound Technology,Anatomy
Cited by
13 articles.
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