Abstract
AbstractCompared to women, increasing male age is not accompanied by such marked changes in reproductive function but changes certainly do happen. These include alterations to the hypothalamo-pituitary-testicular axis, with resultant implications for testosterone production and bioavailability as well as spermatogenesis. There is a decline in sexual function as men age, with a dramatic increase in the prevalence of erectile dysfunction after the age of 40, which is a marker for both clinically evident as well as covert coronary artery disease. Despite a quantitative decline in spermatogenesis and reduced fecundability, the male potential for fertility persists throughout adult life, however there are also increasingly recognised alterations in sperm quality and function with significant implications for offspring health. These changes are relevant to both natural and medically assisted conception.
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Reference143 articles.
1. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194–217.
2. Lambert SM, Masson P, Fisch H. The male biological clock. World J Urol. 2006;24(6):611–7.
3. Pasqualotto FF, Borges Junior E, Pasqualotto EB. The male biological clock is ticking: a review of the literature. Sao Paulo Med J. 2008;126(3):197–201.
4. Matsumoto AM, Marck BT, Gruenewald DA, Wolden-Hanson T, Naai MA. Aging and the neuroendocrine regulation of reproduction and body weight. Exp Gerontol. 2000;35(9–10):1251–65.
5. Pawlikowski M, Winczyk K. Possible role of gonadotropin excess in age-related diseases - return to the old hypothesis in the light of current data. Neuro Endocrinol Lett. 2020;41(3):118–22.
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献