Preliminary Study on the Effect of Blood Purification Therapy with Dual-Cannula in Jugular-Femoral Venous: A Report of 2 Cases

Abstract

Abstract Objective The aim of the study is to investigate whether the multistage draining cannula strategy inserted via the femoral vein and with blood return to the jugular vein can improve the therapeutic efficiency in patients with vena cava drainage disorder compared to traditional hemodialysis therapy. Design This study was approved by the Review Board of the Ethics Committee of Zhongshan Hospital, Fudan University (No. B2022-380), and the need for obtaining signed informed consent was waived for this retrospective analysis. Patients Two adult patients with acute vena cava reflux disorder were analyzed retrospectively in the study. Interventions To minimize recirculation, a multistage draining cannula strategy in a suitable position inserted via the femoral vein and with blood return to the jugular vein was used in patients with vena cava obstruction. Measurements and Main Results Study endpoints included vasopressors equivalent dose, ICU outcome and other clinical outcomes. The results showed that blood purification based on dual-cannula in jugular-femoral venous was able to improve the hemodynamic state, reduce the vasopressors dosage and improve the outcome for critically ill patients with acute vena cava reflux disorder. Conclusions Blood purification therapy with dual-cannula in jugular-femoral venous may be an effective and feasible strategy for patients with acute superior or inferior vena cava “obstruction”.