Author:
Wang Dong,Sun Tongwen,Liu Zhangsuo
Abstract
AbstractSepsis is defined as life-threatening organ dysfunction caused by a dysregulated host immune response to infection. The kidneys are one of the first organs to be injured in sepsis. About two-thirds of patients with septic shock develop acute kidney injury, with a six- to eightfold increase in mortality. Growing evidences elucidate pathophysiological mechanisms, biomarkers, and response to therapy of sepsis-associated acute kidney injury (S-AKI). However, there is still a lack of effective and specific interventions for the treatment of S-AKI. This review summarizes the relevant evidence and provides an overview of the current understanding of S-AKI, focusing on pathophysiology, diagnosis, biomarkers, and therapeutic approaches.
Funder
United Fund of National Natural Science Foundation of China
The National Natural Science Foundation of China
The central government guides local science and technology development funds
Medical Science and Technology Tackling Plan Provincial and Ministerial Major Projects of Henan Province
The special fund for young and middle-aged medical research of China International Medical Exchange Foundation
The integrated thinking research fund of China International Medical Exchange Foundation
Young Talent Recruitment Project
Publisher
Springer Science and Business Media LLC