Cortical 3-hinges could serve as hubs in cortico-cortical connective network
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Published:2020-01-16
Issue:6
Volume:14
Page:2512-2529
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ISSN:1931-7557
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Container-title:Brain Imaging and Behavior
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language:en
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Short-container-title:Brain Imaging and Behavior
Author:
Zhang TuoORCID, Li Xiao, Jiang Xi, Ge Fangfei, Zhang Shu, Zhao Lin, Liu Huan, Huang Ying, Wang Xianqiao, Yang Jian, Guo Lei, Hu Xiaoping, Liu Tianming
Abstract
AbstractMapping the relation between cortical convolution and structural/functional brain architectures could provide deep insights into the mechanisms of brain development, evolution and diseases. In our previous studies, we found a unique gyral folding pattern, termed a 3-hinge, which was defined as the conjunction of three gyral crests. The uniqueness of the 3-hinge was evidenced by its thicker cortex and stronger fiber connections than other gyral regions. However, the role that 3-hinges play in cortico-cortical connective architecture remains unclear. To this end, we conducted MRI studies by constructing structural cortico-cortical connective networks based on a fine-granular cortical parcellation, the parcels of which were automatically labeled as 3-hinge, 2-hinge (ordinary gyrus) or sulcus. On human brains, 3-hinges possess significantly higher degrees, strengths and betweennesses than 2-hinges, suggesting that 3-hinges could serve more like hubs in the cortico-cortical connective network. This hypothesis gains supports from human functional network analyses, in which 3-hinges are involved in more global functional networks than ordinary gyri. In addition, 3-hinges could serve as ‘connector’ hubs rather than ‘provincial’ hubs and they account for a dominant proportion of nodes in the high-level ‘backbone’ of the network. These structural results are reproduced on chimpanzee and macaque brains, while the roles of 3-hinges as hubs become more pronounced in higher order primates. Our new findings could provide a new window to the relation between cortical convolution, anatomical connection and brain function.
Funder
National Natural Science Foundation of China Foundation for the National Institutes of Health National Science Foundation Special Fund for Basic Scientific Research of Central Colleges
Publisher
Springer Science and Business Media LLC
Subject
Behavioral Neuroscience,Psychiatry and Mental health,Cellular and Molecular Neuroscience,Clinical Neurology,Cognitive Neuroscience,Neurology,Radiology Nuclear Medicine and imaging
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