Cognitive changes are associated with increased blood-brain barrier leakage in non-brain metastases lung cancer patients
-
Published:2022-11-22
Issue:1
Volume:17
Page:90-99
-
ISSN:1931-7557
-
Container-title:Brain Imaging and Behavior
-
language:en
-
Short-container-title:Brain Imaging and Behavior
Author:
Zhang Da-Fu,Li Zhen-Hui,Zhang Zhi-Ping,He Yin-Fu,Shang Bin-Li,Xu Xiu-Feng,Ding Ying-Ying,Cheng Yu-Qi
Abstract
AbstractTo explore the relationship between cognitive function and blood–brain barrier leakage in non-brain metastasis lung cancer and healthy controls. 75 lung cancers without brain metastasis and 29 healthy controls matched with age, sex, and education were evaluated by cognitive assessment, and the Patlak pharmacokinetic model was used to calculate the average leakage in each brain region according to the automated anatomical labeling atlas. After that, the relationships between cognitive and blood–brain barrier leakage were evaluated. Compared with healthy controls, the leakage of bilateral temporal gyrus and whole brain gyrus were higher in patients with lung cancers (P < 0.05), mainly in patients with advanced lung cancer (P < 0.05), but not in patients with early lung cancer (P > 0.05). The cognitive impairment of advanced lung cancers was mainly reflected in the damage of visuospatial/executive, and delayed recall. The left temporal gyrus with increased blood–brain barrier leakage showed negative correlations with delayed recall (r = -0.201, P = 0.042). An increase in blood–brain barrier leakage was found in non-brain metastases advanced lung cancers that corresponded to decreased delayed recall. With progression in lung cancer staging, blood–brain barrier shows higher leakage and may lead to brain metastases and lower cognitive development.
Funder
Yunnan digitalization, development and application of biotic resource Innovation Team of Kunming Medical University The National Natural Science Foundation of China The Outstanding Youth Science Foundation of Yunnan Basic Research Project Yunnan Province High-Level Health Technical Talents Yunnan Province Special Project for Famous Medical Talents of the “Ten Thousand Talents Program”
Publisher
Springer Science and Business Media LLC
Subject
Behavioral Neuroscience,Psychiatry and Mental health,Cellular and Molecular Neuroscience,Neurology (clinical),Cognitive Neuroscience,Neurology,Radiology, Nuclear Medicine and imaging
Reference56 articles.
1. Alberg, A. J., Brock, M. V., & Samet, J. M. (2005). Epidemiology of lung cancer: Looking to the future. Journal of Clinical Oncology, 23(14), 3175–3185. https://doi.org/10.1200/jco.2005.10.462 2. Alberg, A. J., Brock, M. V., Ford, J. G., Samet, J. M., & Spivack, S. D. (2013). Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 143(5 Suppl), e1S-e29S. https://doi.org/10.1378/chest.12-2345 3. Andreone, B. J., Chow, B. W., Tata, A., Lacoste, B., Ben-Zvi, A., Bullock, K., Deik, A. A., Ginty, D. D., Clish, C. B., & Gu, C. (2017). Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron, 94(3), 581-594.e585. https://doi.org/10.1016/j.neuron.2017.03.043 4. Andreotti, C., King, A. A., Macy, E., Compas, B. E., & DeBaun, M. R. (2015). The Association of Cytokine Levels With Cognitive Function in Children With Sickle Cell Disease and Normal MRI Studies of the Brain. Journal of Child Neurology, 30(10), 1349–1353. https://doi.org/10.1177/0883073814563140 5. Arvanitis, C. D., Ferraro, G. B., & Jain, R. K. (2020). The blood-brain barrier and blood-tumour barrier in brain tumours and metastases. Nature Reviews Cancer, 20(1), 26–41. https://doi.org/10.1038/s41568-019-0205-x
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|