Use of Antiretrovirals for HIV Prevention: What Do We Know and What Don’t We Know?-Reference-Cited by-同舟云学术

Use of Antiretrovirals for HIV Prevention: What Do We Know and What Don’t We Know?

Published:2013-03-14 Issue:2 Volume:10 Page:142-151
ISSN:1548-3568
Container-title:Current HIV/AIDS Reports
language:en
Short-container-title:Curr HIV/AIDS Rep

Author:

Baeten Jared M.,Grant Robert

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Virology

Link

http://link.springer.com/content/pdf/10.1007/s11904-013-0157-9.pdf

Reference56 articles.

1. Cohen MS, Gay C, Kashuba AD, Blower S, Paxton L. Narrative review: antiretroviral therapy to prevent the sexual transmission of HIV-1. Ann Intern Med. 2007;146:591–601.

2. Baeten J, Celum C. Systemic and topical drugs for the prevention of HIV infection: antiretroviral pre-exposure prophylaxis. Annu Rev Med. 2012;27:27.

3. •• Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365:493–505. This randomized clinical trial provided definitive evidence that use of antiretroviral treatment by HIV-infected persons reduces the risk of HIV transmission to sexual partner. Use of antiretroviral medications for treatment of HIV infected persons to reduce infectiousness and PrEP for HIV uninfected persons to reduce susceptibility are complementary prevention strategies.

4. Donnell D, Baeten JM, Kiarie J, Thomas KK, Stevens W, et al. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet. 2010;375:2092–8.

5. •• Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012;367:399–410. This randomized clinical trial demonstrated that oral PrEP using daily oral FTC/TDF and daily oral TDF alon, was efficacious for prevention of HIV acquisition in both heterosexual men and women who were in HIV serodiscordant partnerships.

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