Understanding and Controlling Chronic Immune Activation in the HIV-Infected Patients Suppressed on Combination Antiretroviral Therapy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology
Link
http://link.springer.com/content/pdf/10.1007/s11904-012-0147-3.pdf
Reference100 articles.
1. • French MA, King MS, Tschampa JM, da Silva BA, Landay AL. Serum immune activation markers are persistently increased in patients with HIV infection after 6 years of antiretroviral therapy despite suppression of viral replication and reconstitution of CD4+ T cells. J Infect Dis. 2009;200:1212–5. This study demonstrated the inability of cART to normalize immune activation markers in HIV-infected patients.
2. • Guaraldi G, Orlando G, Zona S, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin infect Dis. 2011;53(11):1120–6. By showing that non-infectious co-morbidities develop about 15 years earlier despite cART in HIV-infected patients, this study stimulated increased interest in addressing HIV infection as an independent risk factor for a variety of non-AIDS conditions.
3. Antiretroviral Therapy Collaboration. Causes of death in HIV-1-infected individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Clin Infect Dis. 2010;50:1387–96.
4. Cecchinato V, Trindade CJ, Laurence A, et al. Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques. Mucosal Immunol. 2008;1:279–88.
5. Brenchley JM, Paiardini M, Knox KS, et al. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood. 2008;112:2826–35.
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