HIV Persistence in Adipose Tissue Reservoirs
Author:
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology
Link
http://link.springer.com/article/10.1007/s11904-018-0378-z/fulltext.html
Reference127 articles.
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2. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112(12):1821–30. https://doi.org/10.1172/JCI19451 .
3. Pond CM, Mattacks CA. The activation of the adipose tissue associated with lymph nodes during the early stages of an immune response. Cytokine. 2002;17(3):131–9. https://doi.org/10.1006/cyto.2001.0999 .
4. Pond CM. Paracrine relationships between adipose and lymphoid tissues: implications for the mechanism of HIV-associated adipose redistribution syndrome. Trends Immunol. 2003;24(1):13–8. https://doi.org/10.1016/S1471-4906(02)00004-2 .
5. •• Koethe JR, McDonnell W, Kennedy A, Abana CO, Pilkinton M, Setliff I, et al. Adipose tissue is enriched for activated and late-differentiated CD8+ T cells, and shows distinct CD8+ receptor usage, compared to blood in HIV-infected persons. J Acquir Immune Defic Syndr. 2018;77(2):e14–e21. https://doi.org/10.1097/QAI.0000000000001573 . This study demonstrated the presence of HIV-infected CD4 T cells in human adipose tissue and further characterized the TCR repertoire of adipose tissue CD8 T cells.
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