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Cognitive Impairment and Persistent CNS Injury in Treated HIV

  • Published:2016-05-17 Issue:4 Volume:13 Page:209-217
  • ISSN:1548-3568
  • Container-title:Current HIV/AIDS Reports
  • language:en
  • Short-container-title:Curr HIV/AIDS Rep

Author:

Chan Phillip,Hellmuth Joanna,Spudich Serena,Valcour Victor

Funder

National Institute of Mental Health

National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Virology

Reference74 articles.

1. Antiretroviral Therapy Cohort C. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet. 2008;372(9635):293–9. doi: 10.1016/S0140-6736(08)61113-7 .

2. Tozzi V, Balestra P, Bellagamba R, Corpolongo A, Salvatori MF, Visco-Comandini U, et al. Persistence of neuropsychologic deficits despite long-term highly active antiretroviral therapy in patients with HIV-related neurocognitive impairment: prevalence and risk factors. J Acquir Immune Defic Syndr. 2007;45(2):174–82. doi: 10.1097/QAI.0b013e318042e1ee .

3. Burdo TH, Weiffenbach A, Woods SP, Letendre S, Ellis RJ, Williams KC. Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection. AIDS. 2013;27(9):1387–95. doi: 10.1097/QAD.0b013e32836010bd .

4. Garvey LJ, Pavese N, Politis M, Ramlackhansingh A, Brooks DJ, Taylor-Robinson SD, et al. Increased microglia activation in neurologically asymptomatic HIV-infected patients receiving effective ART. AIDS. 2014;28(1):67–72. doi: 10.1097/01.aids.0000432467.54003.f7 . Demonstration of incomplete efficacy of cART in settling intracerebral immune activation despite virologic suppression.

5. Tate DF, Conley J, Paul RH, Coop K, Zhang S, Zhou W, et al. Quantitative diffusion tensor imaging tractography metrics are associated with cognitive performance among HIV-infected patients. Brain Imaging Behav. 2010;4(1):68–79. doi: 10.1007/s11682-009-9086-z .

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