Ursodeoxycholic acid shows antineoplastic effects in bile duct cancer cells via apoptosis induction; p53 activation; and EGFR-ERK, COX-2, and PI3K-AKT pathway inhibition-Reference-Cited by-同舟云学术

Ursodeoxycholic acid shows antineoplastic effects in bile duct cancer cells via apoptosis induction; p53 activation; and EGFR-ERK, COX-2, and PI3K-AKT pathway inhibition

Published:2021-08-14 Issue:9 Volume:48 Page:6231-6240
ISSN:0301-4851
Container-title:Molecular Biology Reports
language:en
Short-container-title:Mol Biol Rep

Author:

Lee Jin^ORCID,Hong Eun Mi,Kim Jung Han,Kim Jung Hee,Jung Jang Han,Park Se Woo,Koh Dong Hee,Jang Hyun Joo

Funder

Hallym Medical Center Academic-Industrial Cooperation Program

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,General Medicine

Link

https://link.springer.com/content/pdf/10.1007/s11033-021-06331-y.pdf

Reference33 articles.

1. Amaral JD, Castro RE, Sola S, Steer CJ, Rodrigues CM (2007) p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. J Biol Chem 282:34250–34259. https://doi.org/10.1074/jbc.M704075200

2. Amaral JD, Viana RJ, Ramalho RM, Steer CJ, Rodrigues CM (2009) Bile acids: regulation of apoptosis by ursodeoxycholic acid. J Lipid Res 50:1721–1734. https://doi.org/10.1194/jlr.R900011-JLR200

3. Blechacz B (2017) Cholangiocarcinoma: current knowledge and new developments. Gut and liver 11:13–26. https://doi.org/10.5009/gnl15568

4. Brandsaeter B, Isoniemi H, Broome U, Olausson M, Backman L, Hansen B, Schrumpf E, Oksanen A, Ericzon BG, Hockerstedt K, Makisalo H, Kirkegaard P, Friman S, Bjoro K (2004) Liver transplantation for primary sclerosing cholangitis; predictors and consequences of hepatobiliary malignancy. J Hepatol 40:815–822. https://doi.org/10.1016/j.jhep.2004.01.002

5. Guicciardi ME, Gores GJ (2002) Ursodeoxycholic acid cytoprotection: dancing with death receptors and survival pathways. Hepatology 35:971–973. https://doi.org/10.1053/jhep.2002.32931

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