Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course
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Published:2021-08-14
Issue:5
Volume:51
Page:592-606
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ISSN:0001-8244
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Container-title:Behavior Genetics
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language:en
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Short-container-title:Behav Genet
Author:
van der Laan Camiel M.ORCID, Morosoli-García José J., van de Weijer Steve G. A., Colodro-Conde Lucía, Ip Hill F., van der Laan Camiel M., Krapohl Eva M. L., Brikell Isabell, Sánchez-Mora Cristina, Nolte Ilja M., Pourcain Beate St, Bolhuis Koen, Palviainen Teemu, Zafarmand Hadi, Colodro-Conde Lucía, Gordon Scott, Zayats Tetyana, Aliev Fazil, Jiang Chang, Wang Carol A., Saunders Gretchen, Karhunen Ville, Hammerschlag Anke R., Adkins Daniel E., Border Richard, Peterson Roseann E., Prinz Joseph A., Thiering Elisabeth, Seppälä Ilkka, Vilor-Tejedor Natàlia, Ahluwalia Tarunveer S., Day Felix R., Hottenga Jouke-Jan, Allegrini Andrea G., Rimfeld Kaili, Chen Qi, Lu Yi, Martin Joanna, Artigas María Soler, Rovira Paula, Bosch Rosa, Español Gemma, Quiroga Josep Antoni Ramos, Neumann Alexander, Ensink Judith, Grasby Katrina, Morosoli José J., Tong Xiaoran, Marrington Shelby, Middeldorp Christel, Scott James G., Vinkhuyzen Anna, Shabalin Andrey A., Corley Robin, Evans Luke M., Sugden Karen, Alemany Silvia, Sass Lærke, Vinding Rebecca, Ruth Kate, Tyrrell Jess, Ehli Erik A., Hagenbeek Fiona A., De Zeeuw Eveline, Van Beijsterveldt Toos C. E. M., Larsson Henrik, Snieder Harold, Verhulst Frank C., Amin Najaf, Whipp Alyce M., Korhonen Tellervo, Vuoksimaa Eero, Rose Richard J., Uitterlinden André G., Heath Andrew C., Madden Pamela, Haavik Jan, Harris Jennifer R., Helgeland Øyvind, Johansson Stefan, Knudsen Gun Peggy S., Njolstad Pal Rasmus, Lu Qing, Rodriguez Alina, Henders Anjali K., Mamun Abdullah, Najman Jackob M., Brown Sandy, Hopfer Christian, Krauter Kenneth, Reynolds Chandra, Smolen Andrew, Stallings Michael, Wadsworth Sally, Wall Tamara L., Silberg Judy L., Miller Allison, Keltikangas-Järvinen Liisa, Hakulinen Christian, Pulkki-Råback Laura, Havdahl Alexandra, Magnus Per, Raitakari Olli T., Perry John R. B., Llop Sabrina, Lopez-Espinosa Maria-Jose, Bønnelykke Klaus, Bisgaard Hans, Sunyer Jordi, Lehtimäki Terho, Arseneault Louise, Standl Marie, Heinrich Joachim, Boden Joseph, Pearson John, Horwood LJohn, Kennedy Martin, Poulton Richie, Eaves Lindon J., Maes Hermine H., Hewitt John, Copeland William E., Costello Elizabeth J., Williams Gail M., Wray Naomi, Järvelin Marjo-Riitta, McGue Matt, Iacono William, Caspi Avshalom, Moffitt Terrie E., Whitehouse Andrew, Pennell Craig E., Klump Kelly L., Burt S. Alexandra, Dick Danielle M., Reichborn-Kjennerud Ted, Martin Nicholas G., Medland Sarah E., Vrijkotte Tanja, Kaprio Jaakko, Tiemeier Henning, Smith George Davey, Hartman Catharina A., Oldehinkel Albertine J., Casas Miquel, Ribasés Marta, Lichtenstein Paul, Lundström Sebastian, Plomin Robert, Bartels Meike, Nivard Michel G., Boomsma Dorret I., Lupton Michelle K., Mitchell Brittany L., McAloney Kerrie, Parker Richard, Burns Jane M., Hickie Ian B., Pool René, Hottenga Jouke-Jan, Martin Nicholas G., Medland Sarah E., Nivard Michel G., Boomsma Dorret I.,
Abstract
AbstractWe test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12–70 years, Australia: 16–73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a ‘rolling weights’ model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41–70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Ecology, Evolution, Behavior and Systematics
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