Author:
Olofsson Jonas K.,Larsson Maria,Roa Catalina,Wilson Donald A.,Jonsson Laukka Erika
Abstract
AbstractOlfactory identification impairment might indicate future cognitive decline in elderly individuals. An unresolved question is to what extent this effect is dependent on the ApoE-ε4, a genotype associated with risk of Alzheimer’s Disease (AD). Given the current concern about reproducibility in empirical research, we assessed this issue in a large sample (n = 1637) of older adults (60 – 96 years) from the population-based longitudinal Swedish National Study on Aging and Care in Kungsholmen (SNAC-K). A hierarchical regression analysis was carried out to determine if a low score on an odor identification test, and the presence of ApoE-ε4, would predict the magnitude of a prospective 6-year change in the Mini-Mental State Examination (MMSE) after controlling for demographic, health-related, and cognitive variables. We found that overall, lower odor identification performance was predictive of cognitive decline, and, as hypothesized, we found that the effect was most pronounced among ApoE-ε4 carriers. Our results from this high-powered sample suggest that in elderly carriers of the ApoE-ε4 allele, odor identification impairment provides an indication of future cognitive decline, which has relevance for the prognosis of AD.
Funder
Knut och Alice Wallenbergs Stiftelse
Riksbankens Jubileumsfond
Vetenskapsrådet
Publisher
Springer Science and Business Media LLC
Subject
Genetics(clinical),Genetics,Ecology, Evolution, Behavior and Systematics
Cited by
18 articles.
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