Using Alternative Definitions of Controls to Increase Statistical Power in GWAS

Author:

Benstock Sarah E.,Weaver Katherine,Hettema John M.,Verhulst Brad

Funder

Office of Extramural Research, National Institutes of Health

Publisher

Springer Science and Business Media LLC

Reference61 articles.

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2. Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson N, Daly MJ, Price AL, Neale BM (2015) LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 47(3):291–295. https://doi.org/10.1038/ng.3211

3. Buniello A, MacArthur JAL, Cerezo M, Harris LW, Hayhurst J, Malangone C, McMahon A, Morales J, Mountjoy E, Sollis E, Suveges D, Vrousgou O, Whetzel PL, Amode R, Guillen JA, Riat HS, Trevanion SJ, Hall P, Junkins H, Parkinson H (2019) The NHGRI-EBI GWAS catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. Nucleic Acids Res 47(D1):D1005–D1012. https://doi.org/10.1093/nar/gky1120

4. Cai N, Revez JA, Adams MJ, Andlauer TFM, Breen G, Byrne EM, Clarke T-K, Forstner AJ, Grabe HJ, Hamilton SP, Levinson DF, Lewis CM, Lewis G, Martin NG, Milaneschi Y, Mors O, Müller-Myhsok B, Penninx BWJH, Perlis RH, Flint J (2020) Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nat Genet 52(4) Article 4. https://doi.org/10.1038/s41588-020-0594-5

5. Coleman JRI, Gaspar HA, Bryois J, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, &, Breen G (2020a) The Genetics of the Mood Disorder Spectrum: genome-wide Association analyses of more than 185,000 cases and 439,000 controls. Biol Psychiatry 88(2):169–184. https://doi.org/10.1016/j.biopsych.2019.10.015

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