Abstract
AbstractDifferences in scaffold design have the potential to influence cell-scaffold interactions. This study sought to determine whether a tri-layer design influences the cellular function of human tenocytes in vitro. The single-layer decellularized, dehydrated human amniotic membrane (DDHAM) and the tri-layer DDHAM (DDHAM-3L) similarly supported tenocyte function as evidenced by improved cell growth and migration, reduced dedifferentiation, and an attenuated inflammatory response. The tri-layer design provides a mechanically more robust scaffold without altering biological activity.
Graphical Abstract
Funder
Celularity Inc.
Rutgers, The State University of New Jersey
Publisher
Springer Science and Business Media LLC
Subject
Biomedical Engineering,Biomaterials,Bioengineering,Biophysics
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