In-Silico Investigation of Osimertinib Based Compounds as Potential Double Mutant EGFR Kinase Inhibitors Against H1975 Cell Line: Integrating QSAR Modeling, Molecular Docking, MD Simulations, and ADME/Tox Studies

Author:

El Bahi Salma,Boutalaka Meryem,Alaqarbeh MarwaORCID,El Alaouy Moulay Ahfid,Koubi Yassine,El Khatabi Khalil,Choukrad M.’barek,Sbai Abdelouahid,Bouachrine Mohammed,Lakhlifi Tahar

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry,Environmental Chemistry,Chemistry (miscellaneous),Catalysis

Reference43 articles.

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5. Finlay MR, Anderton M, Ashton S, Ballard P, Bethel PA, Box MR, Brad-bury RH, Brown SJ, Butterworth S, Campbell A, Chorley C, Colclough N, Cross DA, Currie GS, Grist M, Hassall L, Hill GB, James D, James M, Kemmitt PGL (2014) Wrigley Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem 57:8249–8267

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