Stereoselective synthesis of L-threo-sphingosine, L-ffrreo-sphinganine, D-threo-sphingosine, and D-threo-sphinganinevia oxazoline formation and olefin cross-metathesis; potent protein kinase C inhibitor analogues-Reference-Cited by-同舟云学术

Stereoselective synthesis of L-threo-sphingosine, L-ffrreo-sphinganine, D-threo-sphingosine, and D-threo-sphinganinevia oxazoline formation and olefin cross-metathesis; potent protein kinase C inhibitor analogues

Published:2007-02 Issue:2 Volume:30 Page:167-171
ISSN:0253-6269
Container-title:Archives of Pharmacal Research
language:en
Short-container-title:Arch Pharm Res

Author:

Tian Yong-Shou,Joo Jae-Eun,Pham Van-Thoai,Lee Kee-Young,Ham Won-Hun

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,Drug Discovery,Molecular Medicine

Link

http://link.springer.com/content/pdf/10.1007/BF02977690.pdf

Reference26 articles.

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2. Davis, F. A. and Reddy, G V, Aziridine-2-carboxylic acid mediated asymmetric synthesis ofD-erythro and L-threo-sphingosine from a common precursor.Tetrahedron Letters, 37, 25,4349–4352(1996).

3. Garner, P., Park, J. M., and Malecki, E., A Stereodivergent synthesis of D-erythro-sphingosine and D-threo-sphingosine from L-serine.J. Org. Chem., 53, 4395–4398 (1988).

4. Hannun, Y A., Loomis, C. R., Merrill, A. H. Jr., and Bell, R. M., Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.J. Biol. Chem., 261,12604–12609 (1986).

5. Hannun, Y A., Sphingolipid-mediated signal transduction. Chapman-Hall, New York (1997).

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