The role of inner nuclear membrane proteins in tumourigenesis and as potential targets for cancer therapy

Author:

Rose Maddison,Burgess Joshua T.,O’Byrne Kenneth,Richard Derek J.,Bolderson EmmaORCID

Abstract

AbstractDespite significant advances in our understanding of tumourigenesis and cancer therapeutics, cancer continues to account for 30% of worldwide deaths. Therefore, there remains an unmet need for the development of cancer therapies to improve patient quality of life and survival outcomes. The inner nuclear membrane has an essential role in cell division, cell signalling, transcription, cell cycle progression, chromosome tethering, cell migration and mitosis. Furthermore, expression of several inner nuclear membrane proteins has been shown to be frequently altered in tumour cells, resulting in the dysregulation of cellular pathways to promote tumourigenesis. However, to date, minimal research has been conducted to investigate how targeting these dysregulated and variably expressed proteins may provide a novel avenue for cancer therapies. In this review, we present an overview of the involvement of the inner nuclear membrane proteins within the hallmarks of cancer and how they may be exploited as potent anti-cancer therapeutics.

Funder

Chenhall Research Award

Genomics and Personalised Health Industry Partnership Grant

Queensland University of Technology

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

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