Classification of anticancer drugs: an update with FDA- and EMA-approved drugs

Author:

Ostios-Garcia Lorena,Pérez Daniel Martínez,Castelo Beatriz,Herradón Noelia Hernández,Zamora Pilar,Feliu Jaime,Espinosa Enrique

Abstract

AbstractAnticancer systemic therapy comprises a complex and growing group of drugs. Some of the new agents with novel mechanisms of action that have appeared are difficult to fit in the groups of classical chemotherapy, hormones, tyrosine-kinase inhibitors, and monoclonal antibodies. We propose a classification based on two levels of information: the site of action and the mechanism of action. Regarding the former, drugs can exert their action in the tumor cell, the tumor vasculature, the immune system, or the endocrine system. The mechanism of action refers to the molecular target.

Funder

Universidad Autónoma de Madrid

Publisher

Springer Science and Business Media LLC

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