Author:
Nasr Mostafa M,Lynch Conor C
Abstract
AbstractCirculating tumor cells (CTCs) are known to be prognostic for metastatic relapse and are detected in patients as solitary cells or cell clusters. Circulating tumor cell clusters (CTC clusters) have been observed clinically for decades and are of significantly higher metastatic potential compared to solitary CTCs. Recent studies suggest distinct differences in CTC cluster biology regarding invasion and survival in circulation. However, differences regarding dissemination, dormancy, and reawakening require more investigations compared to solitary CTCs. Here, we review the current state of CTC cluster research and consider their clinical significance. In addition, we discuss the concept of collective invasion by CTC clusters and molecular evidence as to how cluster survival in circulation compares to that of solitary CTCs. Molecular differences between solitary and clustered CTCs during dormancy and reawakening programs will also be discussed. We also highlight future directions to advance our current understanding of CTC cluster biology.
Publisher
Springer Science and Business Media LLC
Reference148 articles.
1. Lianidou, E. S. (2014). Circulating tumor cell isolation: A marathon race worth running. Clinical Chemistry, 60(2), 287–289. https://doi.org/10.1373/clinchem.2013.216010
2. TR, A. (1869). A case of cancer in which cells similar to those in the tumours were seen in the blood after death. The Medical Journal of Australia, 14, 146–147.
3. Hong, Y., Fang, F., & Zhang, Q. (2016). Circulating tumor cell clusters: What we know and what we expect (review). International Journal of Oncology, 49(6), 2206–2216. https://doi.org/10.3892/ijo.2016.3747
4. Dianat-Moghadam, H., Azizi, M., Eslami-S, Z., Cortés-Hernández, L. E., Heidarifard, M., Nouri, M., & Alix-Panabières, C. (2020). The role of circulating tumor cells in the metastatic cascade: Biology, technical challenges, and clinical relevance. Cancers, 12(4). https://doi.org/10.3390/cancers12040867
5. Aceto, N., Bardia, A., Miyamoto, D. T., Donaldson, M. C., Wittner, B. S., Spencer, J. A., Yu, M., Pely, A., Engstrom, A., Zhu, H., & Brannigan, B. W. (2014). Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. Cell, 158(5), 1110–1122. https://doi.org/10.1016/j.cell.2014.07.013
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