Platelets in aging and cancer—“double-edged sword”
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Published:2020-09-01
Issue:4
Volume:39
Page:1205-1221
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ISSN:0167-7659
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Container-title:Cancer and Metastasis Reviews
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language:en
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Short-container-title:Cancer Metastasis Rev
Author:
Faria Alessandra V. S.,Andrade Sheila S.,Peppelenbosch Maikel P.,Ferreira-Halder Carmen V.,Fuhler Gwenny M.
Abstract
AbstractPlatelets control hemostasis and play a key role in inflammation and immunity. However, platelet function may change during aging, and a role for these versatile cells in many age-related pathological processes is emerging. In addition to a well-known role in cardiovascular disease, platelet activity is now thought to contribute to cancer cell metastasis and tumor-associated venous thromboembolism (VTE) development. Worldwide, the great majority of all patients with cardiovascular disease and some with cancer receive anti-platelet therapy to reduce the risk of thrombosis. However, not only do thrombotic diseases remain a leading cause of morbidity and mortality, cancer, especially metastasis, is still the second cause of death worldwide. Understanding how platelets change during aging and how they may contribute to aging-related diseases such as cancer may contribute to steps taken along the road towards a “healthy aging” strategy. Here, we review the changes that occur in platelets during aging, and investigate how these versatile blood components contribute to cancer progression.
Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology
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