Effects of elevated temperature on misonidazole O-demethylation by mouse liver microsomes: kinetic and stability studies of a model mixed-function oxidase reaction

Author:

Walton M. I.,Bleehen N. M.,Workman P.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference37 articles.

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2. Borton P, Carson R, Reed DJ (1974) Stability of suspensions of rat liver microsomes quick-frozen with liquid nitrogen and stored at -85°C. Biochem Pharmacol 23: 2332?2334

3. Clawson RE, Egorin M, Fox BM, Ross LA, Bachur NR (1981) Hyperthermic modification of cyclophosphamide metabolism in rat hepatic microsomes and liver slices. Life Sci 28: 1133?1137

4. Cohen JL, Jao JY (1970) Enzymatic basis of cyclophosphamide activation by hepatic microsomes of the rat. J Pharmacol Exp Ther 174: 206?210

5. Collins FG, Skibba JL (1983) Altered hepatic functions and microsomal activity in perfused rat liver by hyperthermia combined with alkylating agents. Cancer Biochem Biophys 6: 205?211

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