Highly sialylated mucin-type glycopeptide from porcine intestinal mucosa after heparin extraction: O-glycan profiling and immunological activity evaluation

Author:

Zhang Xin,Wang Chen,Han Qing,Chen Xuan,Li Guoyun,Yu Guangli

Funder

National Natural Science Foundation of China

the National Science and Technology Major Project for Significant New Drug Development

Taishan Schalor Climbing Project

Marine S&T Fund of Shandong Province for the Pilot National Laboratory for Marine Science and Technology

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference43 articles.

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2. Johansson, M.E.V., Gustafsson, J.K., Holmen-Larsson, J., Jabbar, K.S., Xia, L., Xu, H., Ghishan, F.K., Carvalho, F.A., Gewirtz, A.T., Sjovall, H., Hansson, G.C.: Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 63(2), 281–291 (2014). https://doi.org/10.1136/gutjnl-2012-303207

3. van der Post, S., Jabbar, K.S., Birchenough, G., Arike, L., Akhtar, N., Sjovall, H., Johansson, M.E.V., Hansson, G.C.: Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis. Gut 68(12), 2142–2151 (2019). https://doi.org/10.1136/gutjnl-2018-317571

4. Bergstrom, K., Shan, X., Casero, D., Batushansky, A., Lagishetty, V., Jacobs, J.P., Hoover, C., Kondo, Y., Shao, B., Gao, L., Zandberg, W., Noyovitz, B., McDaniel, J.M., Gibson, D.L., Pakpour, S., Kazemian, N., McGee, S., Houchen, C.W., Rao, C.V., Griffin, T.M., Sonnenburg, J.L., McEver, R.P., Braun, J., Xia, L.: Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota. Science 370(6515), 467–472 (2020). https://doi.org/10.1126/science.aay7367

5. Behera, S.K., Praharaj, A.B., Dehury, B., Negi, S.: Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases. Glycoconj. J. 32(8), 575–613 (2015). https://doi.org/10.1007/s10719-015-9606-6

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