Hypoxia and TNF-α Synergistically Induce Expression of IL-6 and IL-8 in Human Fibroblast-like Synoviocytes via Enhancing TAK1/NF-κB/HIF-1α Signaling

Author:

Wang Guofen,Wang Junsong,Li Xian,Wu Qiyang,Yao Ruifeng,Luo Xinjing

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Reference45 articles.

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2. Huber, L.C., O. Distler, I. Tarner, R.E. Gay, S. Gay, and T. Pap. 2006. Synovial fibroblasts: Key players in rheumatoid arthritis. Rheumatology (Oxford) 45: 669–675.

3. Yokota, K., T. Miyazaki, M. Hirano, Y. Akiyama, and T. Mimura. 2006. Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Journal of Rheumatology 33: 463–471.

4. Luo, X.J., X.R. Mo, and L.L. Zhou. 2012. The effect of Hsp72 on IL-6, IL-8 expression and activation of NF-kappaB in synoviocytes of rheumatoid arthritis. Zhongguo Ying Yong Sheng Li Xue Za Zhi 28: 336–339.

5. Li, Y., and W. Zhang. 2017. IL-6: The next key target for rheumatoid arthritis after TNF-alpha. Sheng Wu Gong Cheng Xue Bao 33: 36–43.

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