Analysis and Quantification of GPCR Allosteric Receptor–Receptor Interactions Using Radioligand Binding Assays: The A2AR-D2R Heteroreceptor Complex Example

Author:

Borroto-Escuela Dasiel O.,Pérez de la Mora Miguel,Zoli Michele,Benfenati Fabio,Narvaez Manuel,Rivera Alicia,Díaz-Cabiale Zaida,Beggiato Sarah,Ferraro Luca,Tanganelli Sergio,Ambrogini Patrizia,Filip Malgorzata,Liu Fang,Franco Rafael,Agnati Luigi F.,Fuxe Kjell

Publisher

Springer New York

Reference61 articles.

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2. Borroto-Escuela DO, Narvaez M, Perez-Alea M, Tarakanov AO, Jimenez-Beristain A, Mudo G, Agnati LF, Ciruela F, Belluardo N, Fuxe K (2015) Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochem Biophys Res Commun 456(1):489–493. https://doi.org/10.1016/j.bbrc.2014.11.112

3. Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuellar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, Lopez-Gimenez JF, Meana JJ, Benson DL, Gonzalez-Maeso J (2012) Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A.mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 287(53):44301–44319. https://doi.org/10.1074/jbc.M112.413161

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5. Han Y, Moreira IS, Urizar E, Weinstein H, Javitch JA (2009) Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nat Chem Biol 5(9):688–695. https://doi.org/10.1038/nchembio.199

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