Physicochemical Properties and Structural Alerts
Author:
Publisher
Springer New York
Link
http://link.springer.com/content/pdf/10.1007/978-1-4939-7677-5_4
Reference47 articles.
1. Grime KH, Barton P, McGinnity DF (2013) Application of in silico, in vitro and preclinical pharmacokinetic data for the effective and efficient prediction of human pharmacokinetics. Mol Pharm 10(4):1191–1206. https://doi.org/10.1021/mp300476z
2. Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD (2010) Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. J Med Chem 53(3):1098–1108. https://doi.org/10.1021/jm901371v
3. Lipinski CA, Lombardo F, Dominy BW, Feeney PJ (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 23(1–3):3–25. https://doi.org/10.1016/S0169-409X(96)00423-1
4. Smith DA, Di L, Kerns EH (2010) The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery. Nat Rev Drug Discov 9(12):929–939. https://doi.org/10.1038/nrd3287
5. Hollosy F, Valko K, Hersey A, Nunhuck S, Keri G, Bevan C (2006) Estimation of volume of distribution in humans from high throughput HPLC-based measurements of human serum albumin binding and immobilized artificial membrane partitioning. J Med Chem 49(24):6958–6971. https://doi.org/10.1021/jm050957i
Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Mechanism-driven modeling of chemical hepatotoxicity using structural alerts and an in vitro screening assay;Journal of Hazardous Materials;2022-08
2. The integrated use of in silico methods for the hepatotoxicity potential of Piper methysticum;Food and Chemical Toxicology;2020-11
3. Development of Prediction Models for Drug-Induced Cholestasis, Cirrhosis, Hepatitis, and Steatosis Based on Drug and Drug Metabolite Structures;Frontiers in Pharmacology;2020-02-14
4. Predicting the Risks of Drug-Induced Liver Injury in Humans Utilizing Computational Modeling;Challenges and Advances in Computational Chemistry and Physics;2019
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3