Affiliation:
1. Aff1 0000 0000 8517 6224 grid.275559.9 Institute of Human Genetics Uni ver si ty Hos pi tal Jena Am Klinikum 1 07747 Jena Germany
Abstract
Abstract
Hypertension is one of the major risk factors for cardiovascular disease in industrialized societies. Substantial progress has been made in understanding its epidemiology, its pathophysiology, and its associated risks such as coronary artery disease, stroke, and heart failure. Because there is consensus that the abnormal retention of sodium by the kidney is a major important pathophysiological event in hypertension, this review focuses on mechanisms of renal NaCl transport and associated genetic disorders.
Subject
Genetics (clinical),Genetics