Abstract
AbstractIn this work, three genetic regulatory networks are considered, that model the post–transcriptional regulation of the PTEN onco–suppressor gene, mediated by microRNAs and competitive endogenous RNAs, in glioblastoma multiforme, the most severe of brain tumours. We simulate solutions of the resulting stochastic differential systems and discuss the effects of this miRNA–fashioned regulation on PTEN expression.
Funder
Università degli Studi di Urbino Carlo Bo
Publisher
Springer Science and Business Media LLC
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