Factor associated with the occurrence of epilepsy in autism: a systematic review

Author:

Zarakoviti Eleni,Shafran Roz,Skuse David,McTague Amy,Batura Neha,Palmer Tom,Dalrymple Emma,Bennett Sophie D.,Reilly Colin

Abstract

AbstractThis systematic review aimed to identify factors significantly associated with the occurrence of epilepsy in autistic individuals and to consider the impact of study quality on findings. Electronic databases were systematically searched on October 2nd, 2020 and records retrieved were limited to those published from 2000 onwards. Study quality was categorised as ‘good’, ‘moderate’ or ‘weak’. Fifty-three studies were included and in studies where the prevalence of epilepsy was reported (n = 257,892), 18,254 (7%) had co-occurring epilepsy. Intellectual disability/cognitive impairment was the most commonly reported risk factor associated with occurrence of epilepsy in autistic individuals. The evidence supporting other, potentially relevant factors was weak and inconsistent and requires further evaluation. Only 9/53 studies were considered ‘good’ quality.

Funder

Autistica

Young Epilepsy

Epilepsy Research UK

Publisher

Springer Science and Business Media LLC

Subject

Developmental and Educational Psychology

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