Association of Relative Telomere Length and LINE-1 Methylation with Autism but not with Severity

Author:

Salem SohairORCID,Ashaat Engy

Abstract

AbstractAutism is associated with genomic instability, which is regulated by telomere length (TL) and index of global methylation (LINE-1). This study will determine relative TL (RTL) and LINE-1 methylation percentage for 69 patients and 33 control subjects to evaluate their potential role as biomarkers for autism. The results displayed a significant decrease of both RTL and LINE-1 methylation in autistic cases relative to controls (P < 0.001). Analysis of receiver operating characteristics curve revealed that both of RTL and LINE-1 methylation percentage have the ability to serve as autism biomarkers (area under the curve = 0.817 and 0.889, respectively). The statistical analysis revealed positive correlation between the two biomarkers (correlation coefficient = 0.439 and P < 0.001).

Funder

Science and Technology Development Fund (STDF)/ Egypt

National Research Centre Egypt

Publisher

Springer Science and Business Media LLC

Subject

Developmental and Educational Psychology

Reference37 articles.

1. Asghar, M., Bensch, S., Tarka, M., Hansson, B., & Hasselquist, D. (2015). Maternal and genetic factors determine early life telomere length. Proceedings of the Biological Sciences, 282, 20142263.

2. Belancio, V. P. (2015). LINE-1 activity as molecular basis for genomic instability associated with light exposure at night. Mobile Genetic Elements, 5, 1–5.

3. Chang, H. B., Zou, J. Z., He, C., Zeng, R., Li, Y. Y., Ma, F. F., Liu, Z., Ye, H., & Wu, J. X. (2015). Association between long interspersed nuclear element-1 methylation and relative telomere length in Wilms tumor. Chinese Medical Journal (engl), 128, 3055–3061.

4. Costa Dde, S., Rosa, D. V., Barros, A. G., Romano-Silva, M. A., Malloy-Diniz, L. F., Mattos, P., & de Miranda, D. M. (2015). Telomere length is highly inherited and associated with hyperactivity-impulsivity in children with attention deficit/hyperactivity disorder. Frontiers in Molecular Neuroscience, 8, 28.

5. Dong, Y., Huang, Y., Gutin, B., Raed, A., Dong, Y., & Zhu, H. (2017). Associations between global DNA methylation and telomere length in healthy adolescents. Science and Reports, 7, 4210.

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