Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression
-
Published:2021-03-20
Issue:2
Volume:52
Page:522-539
-
ISSN:0162-3257
-
Container-title:Journal of Autism and Developmental Disorders
-
language:en
-
Short-container-title:J Autism Dev Disord
Author:
Liu XianORCID, Zou Mingyang, Sun Caihong, Wu Lijie, Chen Wen-XiongORCID
Abstract
AbstractWe systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring’s autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring’s ASD [OR 0.57, 95% CI 0.41–0.78]. The consumption of a daily amount of at least 400 μg folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36–0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring’s ASD.
Funder
Science and Technology Department of Guangdong Province of China the fund from Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center the key projects fund of Ministry of science and technology of China Science and technology project of Guangzhou Municipal Health Commission
Publisher
Springer Science and Business Media LLC
Subject
Developmental and Educational Psychology
Reference71 articles.
1. Al-Farsi, Y. M., Waly, M. I., Deth, R. C., Al-Sharbati, M. M., Al-Shafaee, M., Al-Farsi, O., Al-Khaduri, M. M., Gupta, I., Ali, A., Al-Khalili, M., & Al-Adawi, S. (2013). Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism. Nutrition, 29(3), 537–541. https://doi.org/10.1016/j.nut.2012.09.014 2. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders. American Psychiatric Association. 3. Bahous, R. H., Jadavji, N. M., Deng, L., Cosín-Tomás, M., Lu, J., Malysheva, O., Leung, K. Y., Ho, M. K., Pallàs, M., Kaliman, P., & Greene, N. D. (2017). High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring. Human Molecular Genetics, 26(5), 888–900. https://doi.org/10.1093/hmg/ddx004 4. Bai, D., Yip, B. H., Windham, G. C., Sourander, A., Francis, R., Yoffe, R., Glasson, E., Mahjani, B., Suominen, A., Leonard, H., & Gissler, M. (2019). Association of genetic and environmental factors with autism in a 5-country cohort. JAMA Psychiatry, 76(10), 1035–1043. https://doi.org/10.1001/jamapsychiatry.2019.1411 5. Bailey, S., & Ayling, J. E. (2009). The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proceedings of the National Academy of Sciences of the United States of America, 106(37), 15424–15429. https://doi.org/10.1073/pnas.0902072106
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|