Isolated Extramedullary Relapse in Childhood Acute Lymphocytic Leukemia
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Hematology
Link
http://link.springer.com/content/pdf/10.1007/s11899-010-0063-9.pdf
Reference48 articles.
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3. Land VJ, Thomas PR, Boyett JM, et al.: Comparison of maintenance treatment regimens for first central nervous system relapse in children with acute lymphocytic leukemia. A Pediatric Oncology Group study. Cancer 1985, 56(1):81–87.
4. Gaynon PS, Trigg ME, Heerema NA et al.: Children’s Cancer Group trials in childhood acute lymphoblastic leukemia: 1983–1995. Leukemia 2000, 14(12):2223–2233.
5. • Nguyen K, Devidas M, Cheng SC, et al.: Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children’s Oncology Group study. Leukemia 2008, 22(12):2142–2150. This article summarizes the Children’s Cancer Group (CCG) data from 1988 until 2002. With such a large cohort, this summary is able to highlight clear differences between groups based on duration of CR1, including both isolated CNS relapse and ITR. In addition, risk factors for relapse are identified, such as NCI risk stratification and initial response to induction chemotherapy.
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