Therapy for Chronic Myelomonocytic Leukemia in a New Era

Author:

Moyo Tamara K.,Savona Michael R.

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Hematology

Reference74 articles.

1. Arber DA, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391–405. doi: 10.1182/blood-2016-03-643544 .

2. Savona MR, et al. An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults. Blood. 2015;125:1857–65. doi: 10.1182/blood-2014-10-607341 .

3. Germing U, Gattermann N, Minning H, Heyll A, Aul C. Problems in the classification of CMML—dysplastic versus proliferative type. Leuk Res. 1998;22:871–8.

4. Nosslinger T, et al. Dysplastic versus proliferative CMML—a retrospective analysis of 91 patients from a single institution. Leuk Res. 2001;25:741–7.

5. •• Patnaik MM, et al. “Proliferative” versus “dysplastic” chronic myelomonocytic leukemia: molecular and prognostic correlates. Blood. 2016;128:1987. Although simply defined by total leukocyte count, Patnaik et al. demonstrated that specific recurrent molecular mutations segregate MD-CMML and MP-CMML. Whereas SF3B1 mutations were more common in MD-CMML, mutations in ASXL1, JAK2, CBL, and genes of the RAS family are more prevalent in MP-CMML, which hints at differential underlying disease biologies. These identified differences will likely impact treatment in the future, especially as targeted therapies are sought. This work led to the WHO recommendation for distinction between MD-CMML and MP-CMML.

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