New Agents in Chronic Lymphocytic Leukemia
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Hematology
Link
http://link.springer.com/content/pdf/10.1007/s11899-009-0039-9.pdf
Reference32 articles.
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2. • Ferrajoli A, Lee BN, Schlette EJ, et al.: Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 2008, 111:5291–5297 This paper describes a phase 2 study that highlighted the clinical activity of lenalidomide in relapsed CLL, but also the hematologic toxicity and tumor flare reaction observed with its use.
3. Ferrajoli A, Keating MJ, Wierda WG, et al.: Lenalidomide is active in patients with relapsed/refractory chronic lymphocytic leukemia (CLL) carrying unfavorable chromosomal abnormalities [abstract]. Blood (ASH Annual Meeting Abstracts) 2007, 110:Abstract 754.
4. Wendtner CM, Mahadevan D, Stilgenbauer S, et al.: Preliminary results of a phase 1/2, multi-center, open-label study (CLL-001) investigating a stepwise dose-escalation schedule of lenalidomide in relapsed or refractory chronic lymphocytic leukemia [abstract]. Blood (ASH Annual Meeting Abstracts) 2008, 112:Abstract 2104.
5. Andritsos LA, Johnson AJ, Lozanski G, et al.: Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia. J Clin Oncol 2008, 26:2519–2525.
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