An Update on the Use of Immunotherapy in the Treatment of Lymphoma
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Hematology
Link
http://link.springer.com/article/10.1007/s11899-017-0396-8/fulltext.html
Reference63 articles.
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2. Golay J, Da Roit F, Bologna L, Ferrara C, Leusen JH, Rambaldi A, et al. Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab. Blood. 2013;122(20):3482–91.
3. Terszowski G, Klein C, Stern M. KIR/HLA interactions negatively affect rituximab—but not GA101 (obinutuzumab)-induced antibody-dependent cellular cytotoxicity. J Immunol. 2014;192(12):5618–24.
4. Vitolo U, Trněný M, Belada D, Carella AM, Chua N, Abrisqueta P, et al. Obinutuzumab or rituximab plus CHOP in patients with previously untreated diffuse large B-cell lymphoma: final results from an open-label, randomized phase 3 study (GOYA). Blood. 2016;128(22):470.
5. •• Goede V, Fischer K, Busch R, Engelke A, Eichhorst B, Wendtner CM, et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med. 2014;370(12):1101–10. The randomized phase 3, CLL11 trial substantiated nearly 20 years of research since the 1997 approval of rituximab to result in the first clinically significant improvement in anti-CD20 antibody therapy, demonstrating a PFS improvement with obinutuzumab versus rituximab (and an OS improvement versus no antibody). Later follow-up demonstrated the OS benefit versus rituximab coming closer towards significance (0.11 in this study, 0.09 in subsequent follow-up). Thus study should inspire continued research into optimization of antibody effector function across different molecular targets, lymphoid and otherwise.
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1. Overview of Targeted Drugs for Mature B-Cell Non-hodgkin Lymphomas;Frontiers in Oncology;2019-06-04
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