Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling-Reference-Cited by-同舟云学术

Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling

Published:2012-10-13 Issue:12 Volume:17 Page:1275-1286
ISSN:1360-8185
Container-title:Apoptosis
language:en
Short-container-title:Apoptosis

Author:

Lee Ju-Hye,Won Yeong-Seon,Park Ki-Hun,Lee Mi-Kyung,Tachibana Hirofumi,Yamada Koji,Seo Kwon-Il

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Biochemistry, medical,Cell Biology,Clinical Biochemistry,Pharmaceutical Science,Pharmacology

Link

http://link.springer.com/content/pdf/10.1007/s10495-012-0767-5.pdf

Reference57 articles.

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2. Pinna GF, Fiorucci M, Reimund JM, Taquet N, Arondel Y, Muller CD (2004) Celastrol inhibits pro-inflammatory cytokine secretion in Crohn’s disease biopsies. Biochem Biophys Res Commun 322:778–786

3. Abbas S, Bhoumik A, Dahl R, Vasile S, Krajewski S, Cosford ND, Ronai ZA (2007) Preclinical studies of celastrol and acetyl isogambogic acid in melanoma. Clin Cancer Res 13:6769–6778

4. Zhang T, Hamza A, Cao X, Wang B, Yu S, Zhan CG, Sun D (2008) A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol Cancer Ther 7:162–170

5. Yang H, Chen D, Cui QC, Yuan X, Dou QP (2006) Celastrol, a triterpene extracted from the Chinese “Thunder of God Vine,” is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res 66:4758–4765

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