FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis

Author:

Wang Jiao,Liu Shu,Yin Yancun,Li Mingjin,Wang Bo,Yang Li,Jiang Yangfu

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Biochemistry, medical,Cell Biology,Clinical Biochemistry,Pharmaceutical Science,Pharmacology

Reference43 articles.

1. Ip SW, Weng YS, Lin SY, Mei-Dueyang, Tang NY, Su CC et al (2007) The role of Ca2+ on rhein-induced apoptosis in human cervical cancer Ca Ski cells. Anticancer Res 27:379–389

2. Lin ML, Chen SS, Lu YC, Liang RY, Ho YT, Yang CY et al (2007) Rhein induces apoptosis through induction of endoplasmic reticulum stress and Ca2+-dependentmitochondrial death pathway in human nasopharyngeal carcinoma cells. Anticancer Res 27:3313–3322

3. Chang CY, Chan HL, Lin HY, Way TD, Kao MC, Song MZ et al (2012) Rhein induces apoptosis in human breast cancer cells. Evid Based Complement Altern Med 2012:952504

4. Lai WW, Yang JS, Lai KC, Kuo CL, Hsu CK, Wang CK et al (2009) Rhein induced apoptosis through the endoplasmic reticulum stress, caspase- and mitochondria-dependent pathways in SCC-4 human tongue squamous cancer cells. In Vivo 23:309–316

5. Miccadei S, Pulselli R, Floridi A (1993) Effect of lonidamine and rhein on the phosphorylation potential generated by respiring rat liver mitochondria. Anticancer Res 13:1507–1510

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