Obstructive sleep apnea-increased DEC1 regulates systemic inflammation and oxidative stress that promotes development of pulmonary arterial hypertension

Author:

Li Xiaoming,Zhang Xiang,Hou Xiaozhi,Bing Xin,Zhu Fangyuan,Wu Xinhao,Guo Na,Zhao Hui,Xu Fenglei,Xia Ming

Funder

Natural Science Foundation of Shandong Province

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Biochemistry (medical),Cell Biology,Clinical Biochemistry,Pharmaceutical Science,Pharmacology

Reference57 articles.

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2. Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR (2019) Immunoglobulin-driven complement activation regulates pro-inflammatory remodeling in Pulmonary Hypertension. American journal of respiratory and critical care medicine. https://doi.org/10.1164/rccm.201903-0591OC

3. Suresh K, Servinsky L, Jiang H, Bigham Z, Zaldumbide J, Huetsch JC, Kliment C, Acoba MG, Kirsch BJ, Claypool SM, Le A, Damarla M, Shimoda LA (2019) Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 317(5):L639–l652. https://doi.org/10.1152/ajplung.00396.2018

4. Minamino T, Christou H, Hsieh CM, Liu Y, Dhawan V, Abraham NG, Perrella MA, Mitsialis SA, Kourembanas S (2001) Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci USA 98(15):8798–8803. https://doi.org/10.1073/pnas.161272598

5. Green DE, Sutliff RL, Hart CM (2011) Is peroxisome proliferator-activated receptor gamma (PPARgamma) a therapeutic target for the treatment of pulmonary hypertension? Pulmonary circulation 1. 33–47. https://doi.org/10.4103/2045-8932.78101. 1

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