Kinetics of ERK1/2 activation determine sensitivity of acute myeloid leukaemia cells to the induction of apoptosis by the novel small molecule ingenol 3-angelate (PEP005)-Reference-Cited by-同舟云学术

Kinetics of ERK1/2 activation determine sensitivity of acute myeloid leukaemia cells to the induction of apoptosis by the novel small molecule ingenol 3-angelate (PEP005)

Published:2010-05-14 Issue:8 Volume:15 Page:946-955
ISSN:1360-8185
Container-title:Apoptosis
language:en
Short-container-title:Apoptosis

Author:

Hampson Peter,Wang Keqing,Milverton Lisa,Ersvaer Elisabeth,Bruserud Oystein,Lord Janet M.

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Biochemistry, medical,Cell Biology,Clinical Biochemistry,Pharmaceutical Science,Pharmacology

Link

http://link.springer.com/content/pdf/10.1007/s10495-010-0507-7.pdf

Reference35 articles.

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3. Hampson P, Chahal H, Khanim F et al (2005) PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood 106:1362–1368

4. Cozzi SJ, Parsons PG, Ogbourne SM, Pedley J, Boyle GM (2006) Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway. Cancer Res 66:10083–10091

5. Choi BH, Hur EM, Lee JH, Jun DJ, Kim KT (2006) Protein kinase Cdelta-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death. J Cell Sci 119:1329–1340

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