Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir

Author:

Patasic Lea,Seifried JannaORCID,Bezler Valerie,Kaljanac Marcell,Schneider Irene C.,Schmitz Heike,Tondera Christiane,Hartmann Jessica,Hombach Andreas,Buchholz Christian J.,Abken Hinrich,König RenateORCID,Cichutek Klaus

Abstract

AbstractChimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR engineered T cells resulting in the depletion of CD4+ target cells aiming for elimination of the human immunodeficiency virus (HIV) reservoir.

Funder

Deutsches Zentrum für Infektionsforschung

Paul-Ehrlich-Institut - Bundesinstitut f├╝r Impfstoffe und biomedizinische Arzneimittel

Publisher

Springer Science and Business Media LLC

Subject

Microbiology (medical),Immunology,General Medicine,Immunology and Allergy

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