Production of Bispecif ic and Trispecific F(ab)2 and F(ab)3 Antibody Derivatives

Author:

French Ruth R.

Publisher

Humana Press

Reference22 articles.

1. Glennie, M. J. and French, R. R (1995) Targeting drugs, toxins and radionuclides with bispecific antibodies, in Bispecific Antibodies (Fanger, M W., ed), Landes, Georgetown, TX, pp 107–120

2. Tutt, A, Stevenson, G. T, and Glennie, M J. (1991) Trispecific F(ab′)3 derivatives that use cooperative signalling via the TCR7CD3 complex and CD2 to activate and redirect resting cytotoxic T cells. J. Immunol 147, 60–69.

3. Nisonoff, A. and Rivers, M. M. (1961) Recombination of a mixture of univalent antibody fragments of different specificity. Arch Biochem Biophys 93, 460–462

4. Karpovsky, B., Titus, J A., Stephany, D A., and Segal, D. M. (1984) Production of target-specific effector cells using hetero-cross-hnked aggregates containing anti-target cell and anti-Feγ receptor antibodies. J Exp Med 160, 1686–1701

5. Jung, G., Freimann, U., and von Marschall Z. (1991) Target-cell induced T-cell activation with bi-and trispecific antibody fragments. Eur. J Immunol 21, 2431–2435.

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