AG2034

Author:

Boritzki Theodore J.,Zhang Cathy,Bartlett Charlotte A.,Jackson Robert C.

Publisher

Humana Press

Reference28 articles.

1. Taylor EC. New pathways from pteridines. Design and synthesis of a new class of potent and selective antitumor agents. J Heterocyclic Chem 1990;27:1–12.

2. Beardsley GP, Taylor EC, Grindey GB, Moran RG. Deaza derivatives of tetrahydrofolic acid. A new class of folate antimetabolite. In: Cooper BA, Whitehead VM, eds. Chemistry and Biology of Pteridines. DeGruyter, Berlin, 1986, pp. 953–957.

3. Shih C, Grindey GB, Houghton PJ, Houghton JA. In vivo antitumor activity of 5,10-dideazatetrahydrofolic acid (DDATHF) and its diastereomeric isomers. Proc Am Assoc Cancer Res 1991; 32:324.

4. Muggia F, Martin T, Ray M, Leichman CG, Grunberg S, Gill I, Moran R, Dyke R, Grindey G. Phase I clinical trial of weekly 5,10-dideazatetrahydrofolate (LY 26418, DDATHF-B). Proc Amer Assoc Clin Oncol 1990; 9:74.

5. Grindey GB, Alati T, Shih C. Reversal of the toxicity but not the antitumor activity of lometrexol by folic acid. Proc Am Assoc Cancer Res 1991; 32:324.

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Three‐component reaction for synthesis of 2‐amino ‐6‐aryl‐5‐(phenylamino)‐3, 7‐dihydro‐4 H ‐pyrrolo[2,3‐ d ]pyrimidin‐4‐one derivatives in water;Journal of Heterocyclic Chemistry;2020-07-07

2. Discovery of 5-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity;Journal of Medicinal Chemistry;2013-12-11

3. Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase;Journal of Medicinal Chemistry;2011-09-22

4. Discovery of Novel Antifolate Inhibitors of De Novo Purine Nucleotide Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter Over the Reduced Folate Carrier for Cellular Entry;Targeted Drug Strategies for Cancer and Inflammation;2011

5. Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry;Journal of Medicinal Chemistry;2010-01-19

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