Genetic Modification of Human Hematopoietic Cells: Preclinical Optimization of Oncoretroviral-mediated Gene Transfer for Clinical Trials

Author:

Budak-Alpdogan Tulin,Rivière Isabelle

Publisher

Humana Press

Reference98 articles.

1. Abonour, R., Williams, D.A., Einhorn, L., Hall, K.M., Chen, J., Coffman, J., et al. (2000) Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells. Nat. Med. 6, 652–658

2. Cornetta, K., Croop, J., Dropcho, E., Abon- our, R., Kieran, M.W., Kreissman, S., et al. (2006) A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-meth-ylguanine DNA methyltransferase. Cancer Gene Ther. 13, 886–895

3. Cowan, K.H., Moscow, J.A., Huang, H., Zujewski, J.A., O'Shaughnessy, J., Sorren-tino, B., et al. (1999) Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multid-rug resistance complementary DNA (MDR1) in metastatic breast cancer patients. Clin. Cancer Res. 5, 1619–1628

4. Hanania, E.G., Giles, R.E., Kavanagh, J., Fu, S.Q., Ellerson, D., Zu, Z., et al. (1996) Results of MDR-1 vector modification trial indicate that granulocyte/macrophage colony-forming unit cells do not contribute to posttransplant hematopoietic recovery following intensive systemic therapy. Proc. Natl. Acad. Sci. U S A 93, 15346–15351

5. Herrera, C., Sanchez, J., Torres, A., Bellido, C., Rueda, A., Alvarez, M.A. (2001) Early-acting cytokine-driven ex vivo expansion of mobilized peripheral blood CD34+ cells generates post-mitotic offspring with preserved engraftment ability in non-obese diabetic/ severe combined immunodeficient mice. Br. J. Haematol. 114, 920–930

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