Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis

Author:

Zhao Tian,Liu Yujie,Hao Yanfei,Zhang Wei,Tao Li,Wang Dong,Li Yuyin,Liu Zhenxing,McKenzie Edward A,Zhao Qing,Diao AipoORCID

Funder

Tianjin Municipal Education Commission

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Reference37 articles.

1. Dall E, Brandstetter H (2015) Structure and function of legumain in health and disease. Biochimie 122(12):126–150

2. Barrett AJ, Rawlings ND (2001) Evolutionary lines of cysteine peptidases. Biol Chem 382(5):727–733

3. Dall E, Brandstetter H (2013) Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. Proc Natl Acad Sci U S A 110(27):10940–10945

4. Chen JM, Dando PM, Rawlings ND et al (1997) Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase. J Biol Chem 272(12):8090–8098

5. Liu C, Sun C, Huang H et al (2003) Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy. Cancer Res 63(11):2957–2964

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