Author:
Li Chao,Zhang Mengdong,Wang Jianwen,Zhang Xiaodong
Abstract
SummaryObjective To compare the efficacy and safety-related outcomes after radical prostatectomy (RP) and permanent seed implantation (PI) using iodine-125 seeds in patients with prostate cancer. Method A retrospective analysis of 196 patients with biopsy-confirmed prostate cancer (T2-T3) was performed in this study. Forty-five patients who underwent PI using iodine-125 seeds combined with endocrine therapy or androgen deprivation therapy (ADT) were compared with 151 patients who underwent RP combined with endocrine therapy or adjuvant ADT. The efficacy and safety outcomes were compared using Kaplan–Meier curves and t-tests. Results Between the RP and PI treatment modalities, no significant difference (P > 0.05) in biochemical recurrence-free survival (BRFS) was observed using Kaplan–Meier curves, regardless of the combination of adjuvant treatment modalities. Furthermore, no significant differences were observed (P > 0.05) with respect to PSA fluctuations, albumin, leukocyte count, urinary and rectal symptoms, erectile function or quality of life (QoL) between the two therapy methods. However, significant differences in the maximum flow rate, average length of hospital stay and indwelling catheter time were observed between the two groups (P < 0.001). Conclusion Iodine-125 seed implantation significantly shortened the average length of hospital stay and indwelling catheter time compared with RP, and the haemoglobin level was significantly higher in the PI group than in the RP group; however, the maximum urine flow rate was lower after of PI than after RP. These two methods showed similar BRFS rates among prostate cancer patients.
Funder
Natural Science Foundation of Beijing Municipality
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology,Oncology
Reference17 articles.
1. Pons-Llanas O, Roldan-Ortega S, Celada-Alvarez F, Perez-Calatayud MJ, Fornes-Ferrer V, Tormo-Mico A, Perez-Calatayud J, Lopez-Torrecilla JL (2018) Permanent seed implant brachytherapy in low-risk prostate cancer: Preoperative planning with 145Gy versus real-time intraoperative planning with 160Gy. Rep Pract Oncol Radiother 23:290–297
2. Gaztanaga M, Crook JM (2013) Permanent seed brachytherapy for locally recurrent prostate cancer after radical prostatectomy: a case report and review of the literature. Brachytherapy 12:338–342
3. Ferreira AS, Guerra MR, Lopes HE, Lima UT, Vasconcelos YA, Teixeira MT (1992) Brachytherapy and radical prostatectomy in patients with early prostate cancer. Rev Assoc Med Bras 61(2015):431–439
4. Kohan AD, Armenakas NA, Fracchia JA (2000) The perioperative charge equivalence of interstitial brachytherapy and radical prostatectomy with 1-year followup. J Urol 163:511–514
5. Grimm PD, Blasko JC, Sylvester JE, Meier RM, Cavanagh W (2001) 10-year biochemical (prostate-specific antigen) control of prostate cancer with (125)I brachytherapy. Int J Radiat Oncol Biol Phys 51:31–40
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