A phase 2 clinical trial of the heat shock protein 90 (HSP 90) inhibitor ganetespib in patients with refractory advanced esophagogastric cancer

Author:

Goyal Lipika,Chaudhary Surendra PalORCID,Kwak Eunice L.,Abrams Thomas A.,Carpenter Amanda N.,Wolpin Brian M.,Wadlow Raymond C.,Allen Jill N.,Heist Rebecca,McCleary Nadine Jackson,Chan Jennifer A.,Goessling Wolfram,Schrag Deborah,Ng Kimmie,Enzinger Peter C.,Ryan David P.,Clark Jeffrey W.

Funder

National Cancer Institute

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Reference24 articles.

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2. Sohda M, Kuwano H (2017) Current status and future prospects for Esophageal Cancer treatment. Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 23(1):1–11. https://doi.org/10.5761/atcs.ra.16-00162

3. Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, Aprile G, Kulikov E, Hill J, Lehle M, Ruschoff J, Kang YK (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet (London, England) 376(9742):687–697. https://doi.org/10.1016/s0140-6736(10)61121-x

4. Zuehlke A, Johnson JL (2010) Hsp90 and co-chaperones twist the functions of diverse client proteins. Biopolymers 93(3):211–217. https://doi.org/10.1002/bip.21292

5. Modi S, Stopeck A, Linden H, Solit D, Chandarlapaty S, Rosen N, D’Andrea G, Dickler M, Moynahan ME, Sugarman S, Ma W, Patil S, Norton L, Hannah AL, Hudis C (2011) HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 17(15):5132–5139. https://doi.org/10.1158/1078-0432.Ccr-11-0072

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