Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study-Reference-Cited by-同舟云学术

Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study

Published:2010-05-08 Issue:5 Volume:29 Page:891-900
ISSN:0167-6997
Container-title:Investigational New Drugs
language:en
Short-container-title:Invest New Drugs

Author:

Beck Raphaël,Pedrosa Rozangela Curi,Dejeans Nicolas,Glorieux Christophe,Levêque Philippe,Gallez Bernard,Taper Henryk,Eeckhoudt Stéphane,Knoops Laurent,Calderon Pedro Buc,Verrax Julien

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Link

http://link.springer.com/content/pdf/10.1007/s10637-010-9441-3.pdf

Reference33 articles.

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3. Sun Y, Oberley LW, Elwell JH, Sierra-Rivera E (1989) Antioxidant enzyme activities in normal and transformed mouse liver cells. Int J Cancer 44(6):1028–1033

4. Verrax J, Cadrobbi J, Marques C, Taper H, Habraken Y, Piette J, Calderon PB (2004) Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death. Apoptosis 9(2):223–233

5. Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, Chiao PJ, Achanta G, Arlinghaus RB, Liu J, Huang P (2006) Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 10(3):241–252

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