Erlotinib pharmacokinetics: a critical parameter influencing acute toxicity in elderly patients over 75 years-old

Author:

Bigot Frederic,Boudou-Rouquette Pascaline,Arrondeau Jennifer,Thomas-Schoemann Audrey,Tlemsani Camille,Chapron Jeanne,Huillard Olivier,Cessot Anatole,Vidal Michel,Alexandre Jerome,Blanchet Benoit,Goldwasser Francois

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Reference18 articles.

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2. Shepherd FA, Rodrigues Pereira J, Ciuleanu T, Tan EH, Hirsh V, Thongprasert S, Campos D, Maoleekoonpiroj S, Smylie M, Martins R, van Kooten M, Dediu M, Findlay B, Tu D, Johnston D, Bezjak A, Clark G, Santabárbara P, Seymour L (2005) Erlotinib in previously treated non–small-cell lung cancer. N. Engl J Med 353(2):123–132

3. Chen Y-M, Lai C-H, Rau K-M, Huang C-H, Chang H-C, Chao T-Y, Tseng C-C, Fang W-F, Chen Y-C, Chung Y-H, Wang Y-H, Su M-C, Huang K-T, Liu S-F, Chen H-C, Chang Y-C, Chang Y-P, Wang C-C, Lin M-C Advanced non-Small cell lung cancer patients at the extremes of age in the era of epidermal growth factor receptor tyrosine kinase inhibitors. Lung Cancer 98:99–105

4. Wheatley-Price P, Ding K, Seymour L, Clark GM, Shepherd FA (2008) Erlotinib for advanced non–small-cell lung cancer in the elderly: an analysis of the national cancer institute of canada clinical trials group study BR.21. J. Clin. Oncol. 26(14):2350–2357

5. Jackman DM, Yeap BY, Lindeman NI, Fidias P, Rabin MS, Temel J, Skarin AT, Meyerson M, Holmes AJ, Borras AM, Freidlin B, Ostler PA, Lucca J, Lynch TJ, Johnson BE, Jänne PA (2007) Phase II clinical trial of chemotherapy-Naïve patients ≥70 Years of age treated with erlotinib for advanced non–small-cell lung cancer. J. Clin Oncol 25(7):760–766

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