Rapamycin synergizes the cytotoxic effects of MEK inhibitor binimetinib and overcomes acquired resistance to therapy in melanoma cell lines in vitro
Author:
Funder
Russian Science Foundation
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology,Oncology
Link
https://link.springer.com/content/pdf/10.1007/s10637-021-01089-3.pdf
Reference39 articles.
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2. McCubrey JA, Steelman LS, Kempf CR et al (2011) Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways. J Cell Physiol 226:2762–2781. https://doi.org/10.1002/jcp.22647
3. Calero R, Morchon E, Martinez-Argudo I, Serrano R (2017) Synergistic anti-tumor effect of 17AAG with the PI3K/mTOR inhibitor NVP-BEZ235 on human melanoma. Cancer Lett 406:1–11. https://doi.org/10.1016/j.canlet.2017.07.021
4. Chappell WH, Steelman LS, Long JM, et al (2011) Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget 2:135–164. https://doi.org/10.18632/oncotarget.240
5. Wang A-X, Qi X-Y (2013) Targeting RAS/RAF/MEK/ERK signaling in metastatic melanoma. IUBMB Life 65:748–758. https://doi.org/10.1002/iub.1193
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